Journal article
Phytochemical Profiling and Biological Testing of the Constituents of the Australian Plant Haemodorum brevisepalum
EO Norman, S Hombsch, J Lever, R Brkljača, J White, RB Gasser, AC Taki, S Urban
Journal of Natural Products | AMER CHEMICAL SOC | Published : 2021
Abstract
Phytochemical profiling was undertaken on the crude extracts of the bulbs, stems, and the fruits of Haemodorum brevisepalum, to determine the nature of the chemical constituents present. This represents the first study to investigate the fruits of a species of Haemodorum. In total, 13 new and 17 previously reported compounds were isolated and identified. The new compounds were of the phenylphenalenone-type class, with a representative of a novel structural form, named tentatively "oxabenzochromenone"(1), a compound akin to an intermediate in a recently proposed phenylphenalenone metabolic network (2), seven new phenylphenalenones (4-10), four new phenylbenzoisochromenones (11-14), and a new ..
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Grants
Awarded by Wellcome Trust
Funding Acknowledgements
The antimicrobial screening performed by CO-ADD (The Community for Antimicrobial Drug Discovery) was funded by the Wellcome Trust (UK) and The University of Queensland (Australia). E.O.N. would like to acknowledge the financial support awarded under the Research Stipend Scholarship (RSS) scheme provided by the Australian Government via RMIT University. The anthelmintic discovery project was funded by Yourgene Health Singapore Pty. Ltd. and the Australian Research Council (ARC Grant No. LP190101209; R.B.G.). J.M.W. acknowledges funding from the ARC LIEF Scheme (Grant No. LE170100065). This research was undertaken in part using the MX2 beamline at the Australian Synchrotron, part of ANSTO, and made use of the Australian Cancer Research Foundation (ACRF) detector.